PROBLEM TO BE SOLVED: To provide a new transdermal delivery composition which solves the disadvantages experienced by the current transdermal delivery techniques. A composition for use in delivering an active substance to the stratum corneum, which is in the form of a complex with an active substance, is a sintered body, and has uniform and hard spherical nanopore calcium phosphate particles, With a topical delivery vehicle component, the particles dissolve under the physiologically acidic conditions of the stratum corneum. [Selection diagram] FIG. 1A【課題】現在の経皮送達手法によって経験される不利な点を解決する、新しい経皮送達組成物を提供する。【解決手段】角質層へ活性物質を送達する用途に用いられる組成物であって、活性物質と複合体形成されており、焼結体であり、均一で硬い球状のナノ細孔リン酸カルシウム粒子と、局所送達ビヒクル成分とを含み、前記粒子は、角質層の生理学的酸性状態の下で溶解する。【選択図】図１Ａ
