Academisch Ziekenhuis Leiden A/U Leiden Uni Medical CTR;Janssen Pharmaceutica NV
发明人:
申请号：
EP19165320.3
公开号：
EP3581581A1
申请日:
2012.02.02
申请国别(地区):
EP
年份:
2019
代理人:
摘要：
The present invention stems from the finding that two genes designated R2R1 and R2R2, play important roles in tissue development and cancer biology. In particular, the inventors have discovered that these two genes are expressed in pulmonary cells and are required for late branching morphogenesis of pulmonary epithelium and endothelium and support the development/maintenance of the refined three dimensional architecture of the lung. These genes are essential in the squamous differentiation program and development/ maintenance of the progenitor (Krtl4 expressing) cell pool. Moreover, the inventors have identified crucial roles for these genes in cancer biology, particularly processes associated with the acquisition of an immortal and metastatic phenotype (including cancer progression and metastasis) and pulmonary and cardiac development. Accordingly, the invention provides compounds and methods for use in the treatment of cardiac and pulmonary diseases and well as in cancer.
