ACADEMISCH ZIEKENHUIS LEIDEN A/U LEIDEN UNI MEDICAL CTR;JANSSEN PHARMACEUTICA NV
发明人:
AERSSENS, JEROEN MARCEL MARIA ROGER,VAN BREMPT, RONALD KAREL LOUISA,PEETERS, PIETER JOHAN,DE HOOGT, RONALD ANTHONIUS,DE RUITER, MARCUS CORNELIS
申请号：
CA2826490
公开号：
CA2826490A1
申请日:
2012.02.02
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The present invention stems from the finding that two genes designated R2R1 and R2R2, play important roles in tissue development and cancer biology. In particular, the inventors have discovered that these two genes are expressed in pulmonary cells and are required for late branching morphogenesis of pulmonary epithelium and endothelium and support the development/maintenance of the refined three dimensional architecture of the lung. These genes are essential in the squamous differentiation program and development/ maintenance of the progenitor (Kit 14 expressing) cell pool. Moreover, the inventors have identified crucial roles for these genes in cancer biology, particularly processes associated with the acquisition of an immortal and metastatic phenotype (including cancer progression and metastasis) and pulmonary and cardiac development. Accordingly, the invention provides compounds and methods for use in the treatment of cardiac and pulmonary diseases and well as in cancer.
