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METHOD FOR TREATING DISEASES ASSOCIATED WITH EXPOSURE TO ALKYLating SUBSTANCES
专利权人:
НЭШНЛ ДЖУИШ ХЕЛТ (US)
发明人:
ДЭЙ Брайан Дж. (US),УАЙТ Карл В. (US)
申请号:
RU2010152638/15
公开号:
RU2010152638A
申请日:
2009.05.26
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
1. A method for treating a lesion associated with exposure to an alkylating agent in a subject, said method comprising the step of:! the introduction to the needy in this subject an effective amount of a compound of the formula! ! or a pharmaceutically acceptable salt thereof,! where R1, R2, R3 and R4 each independently represent! ! where R5, R6 and R7 are each independently selected from the group consisting of unsubstituted or substituted alkyl, unsubstituted or substituted heteroalkyl, unsubstituted or substituted heterocycloalkyl, unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, halogen, - CN, —CF3, —OH, —NH2, and —COOH. ! 2. The method according to claim 1, where the compound is associated with a metal. ! 3. The method according to claim 2, where the metal is selected from the group consisting of manganese, iron, cobalt, copper, nickel and zinc. ! 4. The method according to claim 3, where the compound is associated with manganese. ! 5. The method according to claim 1, where R5, R6 and R7, independently, are substituted or unsubstituted C1-20 alkyl. ! 6. The method according to claim 5, where R5, R6 and R7, independently, are substituted or unsubstituted C1-10 alkyl. ! 7. The method according to claim 6, where R5, R6 and R7 are independently selected from the group consisting of hydrogen, methyl, ethyl and propyl. ! 8. The method according to claim 7, where R1, R2, R3 and R4 are independently selected from the group consisting of! ! 9. The method of claim 8, where the compound has a formula selected from the group consisting of! ! 10. The method according to claim 1, where R1, R2, R3 and R4 are independently selected from the group consisting of! ! 11. The method according to claim 10, where the compound has a formula selected from the group consisting of! ! 12. The method according to claim 1, where the lesion is a lesion of an organ in a subject. ! 13. The method of claim 12, wherein the organ is skin, lungs, nose,1. Способ лечения п
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