KARLSSON Jan Olof G. (NO),КАРЛССОН Ян Олоф Г. (NO),KURTs Tino (SE),КУРЦ Тино (SE),ANDERSSON Rol'f (SE),АНДЕРССОН Рольф (SE),KARLSSON JAN OLOF G.,КАРЛССОН Ян Олоф Г.,KURTS TINO,КУРЦ Тино,ANDERSSON ROLF,АНДЕРССОН Рольф
申请号：
RU2010129038/04
公开号：
RU0002491282C2
申请日:
2008.12.12
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to a method of treating cancer in a patient, wherein the method involves administering a cancer-inhibiting amount of a compound of formula I into a patient's body. The method of treating cancer in the patient, including a human, wherein the method involves administering the cancer-inhibiting amount of a first compound of formula I or a physiologically acceptable salt thereof into the patient's body, wherein X represents CH or N, each R1 independently represents hydrogen or -CH2COR5； R5 represents hydroxy, optionally hydroxylated alkoxy, amino or alkylamino； each R2 independently represents the group ZYR6； Z represents a bond or the C1-3 alkylene or oxoalkylene group optionally substituted by the group R7； Y represents a bond, an oxygen atom or the group NR6； R6 is a hydrogen atom, the group COOR8, the alkyl, alkenyl, cycloalkyl, aryl or aralalkyl group optionally substituted by one or more groups COOR8, CONR8 2, NR8 2, OR8, =NR8, =O, OP(O)(OR8)R7 and OSO3M； R7 is hydroxy, the optionally alkoxylated or aminoalkyl group； R8 is a hydrogen atom or the optionally hydroxylated, optionally alkoxylated alkyl group； M is a hydrogen atom or one equivalent of a physiologically acceptable cation； R3 represents the C1-8 alkylene group, 1,2-cycloalkylene group or 1,2-arylene group, optionally substituted by R7； and each R4 independently represents hydrogen or C1-3 alkyl.EFFECT: invention refers to a pharmaceutical composition for treating cancer in the patient, containing the compound of formula I, as well as to a kit for treating cancer.23 cl, 3 ex, 7 dwgИзобретение относится к способу лечения рака у пациента, где способ включает введение в организм пациента ингибирующего рак количества первого соединения формулы Способ лечения рака у пациента, включая человека, где указанный способ включает введение в организм пациента ингибирующего рак количества первого соединения формулы Iили егофизиологически приемлемой соли, где
