The present invention relates to a kind of polynucleotides to be configured to treatment retinal degenerative disease, such as retinitis pigmentosa (RP), the carrier of nucleic acid, it includes the polynucleotides, a kind of pharmaceutical composition, carrier comprising the nucleic acid, kit, the carrier comprising the polynucleotides or the nucleic acid, the method for preparing polypeptide, the carrier of the nucleic acid, and treatment retinal degenerative disease.