Andreas Evers,Christopher Kallus,Michael Wagner,Hermut Wehlan
申请号:
US14895695
公开号:
US20160137618A1
申请日:
2014.06.05
申请国别(地区):
US
年份:
2016
代理人:
摘要:
The present invention relates to macrocydic urea derivatives of the formula I (I) in which R1, R2, R3, V and Y are as defined below. The compounds of the formula I are inhibitors of the enzyme TAFIa (activated thrombin-activatable fibrinolysis inhibitor). The invention further relates to the process for the preparation of the compounds of formula I and to the use thereof as medicaments.