PROBLEM TO BE SOLVED: To provide a method of producing a transdermal absorption sheet capable of reducing the tact time of the drug solution filling step and the drying step to improve the production efficiency compared with the related art.SOLUTION: The method includes: a preparatory step S1 of forming a sheet portion 116 in advance by drying and solidifying a base solution A in a thin film state a drug solution deposition step S2 of depositing a drug solution B comprising a drug on a surface of a mold 13 having a plurality of minute needle-like recessed portions 15 being arranged two-dimensionally a drug solution filling step S3 of filling the needle-like recessed portions 15 with the drug solution B by pressing the drug solution B deposited on the surface of the mold 13 against the surface of the mold by the sheet portion 116 to pressingly spread the drug solution B over the surface of the mold 13 a drying step S4 of drying an undried drug solution filled B in the needle-like recessed portions 15 along with the sheet portion 116 to form needle-like protruding portions 110 on a lower surface of the sheet portion 116 and a peeling-off step S5 of peeling off the sheet portion 116 and the needle-like protruding portions 110 from the mold 13.SELECTED DRAWING: Figure 8COPYRIGHT: (C)2018,JPO&INPIT【課題】薬液充填工程及び乾燥工程においてタクト時間を短縮でき、従来よりも生産効率を向上できる経皮吸収シートの製造方法を提供する。【解決手段】基材液Aを薄膜状に乾燥固化してシート部116を予め形成しておく前準備工程S1、複数の微細な針状凹部15が2次元配列されたモールド13の表面に、薬剤を含む薬液Bを配置する薬液配置工程S2と、モールド13の表面に配置された薬液Bを、シート部116でモールド表面に押し付けることにより、薬液Bをモールド13の表面に押し広げながら針状凹部15に充填する薬液充填工程S3と、針状凹部15に充填された未乾燥の薬液Bをシート部116と一緒に乾燥することによりシート部116の下面に針状凸部110を形成する乾燥工程S4と、シート部116と針状凸部110とをモールド13から剥離する剥離工程S5と、を備える。【選択図】図8
