A kind of real-time, the image-guided high intensity focused ultrasound (HIFU) of system and method offer targets and treatment tissue. In one embodiment, system includes the tissue of the three-dimensional visualization of HIFU applicators and user and touch-screen display. Picture frame shows that the tissue for describing realtime graphic on a user interface, including image are parallel to feature device and image perpendicular to parallel image. Reference line can be delineated using touch screen and display picture frame. In one embodiment, organizational boundary is detected and is marked in picture frame, or is started automatically by user or by system. In another embodiment, user interface includes floor push for user and system interaction. In another embodiment, system includes that ultrasonic imaging component is configured as disengaging with system as independent supersonic imaging apparatus.