This application involves the protein and peptide that modified albumen includes coiled-coil domain there is sequence number 1:ZXBBBBZ as shown in SEQ to be connected to the structural domain can be coiled-coil domain, in which: Z is any amino acid or is absolutely correct X is any amino acid B arginine (R values) or lysine (). The modified protein is in specific antigen or carrier protein, is associated with antigen. This modified protein has the electronegative polymer of the affinity such as nucleic acid or heparin of enhancing, and shows increased immunogenicity.
