VAN DER GRAAF, ADRIANUS CORNELIS,HENNING, ROBERT HENK,DEELMAN, LEO EDWIN,EUVERINK, GERRIT JAN WILLEM
申请号：
CA2986300
公开号：
CA2986300A1
申请日:
2016.05.12
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The present invention relates to compounds for prophylaxis or treatment of organ damage by restoring endothelial function and/or inhibiting reactive oxygen species production and especially to compounds for prophylaxis or treatment of diabetic kidney damage. Specifically, the present invention relates to 6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)(piperazin-1-yl)methanone or N,6-dihydroxy-2,5,7,8-tetramethylchroman-2-carboxamide or a pharmaceutically acceptable salt or base thereof for use in the prophylaxis or treatment of organ damage by restoring endothelial function and/or inhibiting reactive oxygen species production and especially diabetic kidney organ damage.
