Adrianus Cornelis VAN DER GRAAF,Robert Henk HENNING,Leo Edwin DEELMAN,Gerrit Jan Willem EUVERINK
申请号：
US15576290
公开号：
US20180170892A1
申请日:
2016.05.12
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to compounds for prophylaxis or treatment of organ damage by restoring endothelial function and/or inhibiting reactive oxygen species production and especially to compounds for prophylaxis or treatment of diabetic kidney damage. Specifically, the present invention relates to 6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)(piperazin-1-yl)methanone or N,6-dihydroxy-2,5,7,8-tetramethylchroman-2-carboxamide or a pharmaceutically acceptable salt or base thereof for use in the prophylaxis or treatment of organ damage by restoring endothelial function and/or inhibiting reactive oxygen species production and especially diabetic kidney organ damage.
