Pawel Grzywacz;Hector F. DeLuca;Margaret Clagett-Dame;Lori A. Plum;Grazia Chiellini
发明人:
Hector F. DeLuca,Margaret Clagett-Dame,Lori A. Plum,Grazia Chiellini,Pawel Grzywacz
申请号：
US12343586
公开号：
US08609643B2
申请日:
2008.12.24
申请国别(地区):
US
年份:
2013
代理人:
摘要：
This invention discloses 2-methylene-(20S,25R)-19,26-dinor-vitamin D analogs, and specifically 2-methylene-(20S,25R)-19,26-dinor-1α,25-dihydroxyvitamin D3, and pharmaceutical uses therefor. This compound exhibits pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion. This compound also has little, if any, calcemic activity and therefore may be used to treat autoimmune disorders or inflammatory diseases in humans as well as renal osteodystrophy. This compound may also be used for the treatment or prevention of obesity.
