Rafal R. Sicinski;Hector F. DeLuca;Margaret Clagett-Dame;Lori A. Plum
发明人:
Hector F. DeLuca,Rafal R. Sicinski,Lori A. Plum,Margaret Clagett-Dame
申请号：
US13302709
公开号：
US20120071562A1
申请日:
2011.11.22
申请国别(地区):
US
年份:
2012
代理人:
摘要：
This invention discloses 2α-methyl-19-nor-(20S)-vitamin D analogs, and specifically 2α-methyl-19-nor-(20S)-1α-hydroxy-bishomopregnacalciferol and pharmaceutical uses therefor. This compound exhibits pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion. This compound also has little, if any, calcemic activity and therefore may be used to treat autoimmune disorders or inflammatory diseases in humans as well as renal osteodystrophy. This compound may also be used for the treatment or prevention of obesity.
