Disclosed are 2-methylene-(20S,25S)-19,27-dinor-(22E)-vitamin D analogs, in particular the compound is 2-methylene-(20S,25S)-19,27-dinor-(22E)-1alpha,25- dihydroxyvitamin D3. This compound can be used as an anti-cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion. This compound also has little, if any, calcemic activity and therefore may be used to treat autoimmune disorders or inflammatory diseases in humans as well as renal osteodystrophy. This compound may also be used for the treatment or prevention of obesity.
