The present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the formula (I) wherein R1, R2, R3, R5, R6 and R8 are each independently a member selected from the group consisting of H, C1-6 alkyl and OH； R4, R7 and R9 are each independently selected from the group consisting of C1-6 alkoxy and OH； R10 is a member selected from the group consisting of H, -OH, -OP(O)Me2, (II) -O-(CH2)n-OH and -O-(CH2)m-O-(CH2)o- CH3, wherein subscripts n and m are each independently from 2 to 8 and subscript o is from 1 to 6； each of L1 and L4 are independently selected from the group consisting of: (III) each of L and L3 are independently selected from the group consisting of: (IV) salts, hydrates, isomers, metabolites and prodrugs thereof.
