The present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the formula:wherein R1, R2, R3, R5, R6, R8, M1, M2, M3, M4, M5, M6 and M7 are each independently a member selected from the group consisting of H, C1-6 alkyl, OH and C1-6 hydroxyalkyl； R4, R7 and R9 are each independently selected from the group consisting of C1-6 alkoxy and OH； R10 is a member selected from the group consisting of H, —；OH, —；OP(O)Me2,—；O—；(CH2)n—；OH and —；O—；(CH2)m—；O—；(CH2)o—；CH3, wherein subscripts n and m are each independently from 2 to 8 and subscript o is from 1 to 6； each of L1 and L4 are independently selected from the group consisting of:wherein each M8 is independently a member selected from the group consisting of C1-6 alkyl, OH and C1-6 hydroxyalkyl； each of L2 and L3 are independently selected from the group consisting of:and salts, hydrates, isomers, metabolites, N-oxides and prodrugs thereof.
