The present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the formula (I) wherein R 1 , R 2 , R 3 , R 5 , R 6 and R 8 are each independently a member selected from the group consisting of H, C 1-6 alkyl and OH； R 4 , R 7 and R 9 are each independently selected from the group consisting of C 1-6 alkoxy and OH； R 10 is a member selected from the group consisting of H, -OH, -OP(O)Me 2 , (II) -O-(CH 2 ) n -OH and -O-(CH 2 ) m -O-(CH 2 ) o - CH 3 , wherein subscripts n and m are each independently from 2 to 8 and subscript o is from 1 to 6； each of L 1 and L 4 are independently selected from the group consisting of: (III) each of L and L3 are independently selected from the group consisting of: (IV) salts, hydrates, isomers, metabolites and prodrugs thereof.
