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Ointment with excellent formulation stability
专利权人:
Tomoki Sakaguchi
发明人:
Tomoki Sakaguchi,Hidetoshi Emi
申请号:
US14008413
公开号:
US09555025B2
申请日:
2012.03.28
申请国别(地区):
US
年份:
2017
代理人:
摘要:
Provided is an ointment which has excellent drug stability and excellent drug uniformity. The ointment, which comprises 1 to 5% by weight of 1-[2-[(4S)-4-hydroxy-1,2,3,4-tetrahydroquinolin-1-yl]-4-pyridyl]-2,3-bis(hydroxymethyl)-6,7-dimethoxynaphthalene·3/2 hydrate, 3 to 7% by weight of a separation inhibitor, 15 to 50% by weight of a hydrocarbon gel, a pH controller and 0.05 to 0.4% by weight of an antioxidant, has excellent drug stability and excellent drug dispersibility. In the present ointment, polyoxyethylene (196) polyoxypropylene (67) glycol is preferred as the separation inhibitor, diisopropanolamine is preferred as the pH controller, and dibutylhydroxytoluene is preferred as the antioxidant.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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