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OINTMENT WITH EXCELLENT FORMULATION STABILITY
专利权人:
MARUHO CO.; LTD.
发明人:
SAKAGUCHI, TOMOKI,EMI, HIDETOSHI
申请号:
EP12762791
公开号:
EP2692347A4
申请日:
2012.03.28
申请国别(地区):
EP
年份:
2014
代理人:
摘要:
Provided is an ointment which has excellent drug stability and excellent drug uniformity. The ointment, which comprises 1 to 5% by weight of 1-[2-[(4S)-4-hydroxy-1,2,3,4-tetrahydroquinolin-1-yl] -4-pyridyl] -2,3-bis(hydroxymethyl)-6,7-dimethoxynaphthalene·3/2 hydrate, 3 to 7% by weight of a separation inhibitor, 15 to 50% by weight of a hydrocarbon gel, a pH controller and 0.05 to 0.4% by weight of an antioxidant, has excellent drug stability and excellent drug dispersibility. In the present ointment, polyoxyethylene (196) polyoxypropylene (67) glycol is preferred as the separation inhibitor, diisopropanolamine is preferred as the pH controller, and dibutylhydroxytoluene is preferred as the antioxidant.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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