PROBLEM TO BE SOLVED: To acquire clear fluorescence images for facilitating discrimination of lesion tissue and normal tissue by eliminating the influence of noise light originated in a light guide part by simple computation.SOLUTION: This fluorescence endoscope apparatus 1 is provided with: an insertion part 2 to be inserted into a body cavity a light source part 3 arranged on the proximal end side of the insertion part 2 for generating excitation light and reference light including at least a part of the wavelength band of fluorescence generated by the excitation light the light guide part 6 for guiding the excitation light and the reference light to the distal end side of the insertion part 2 an irradiation control part 14 for switching the first irradiation state of irradiating a wall A inside the body cavity with the excitation light and the second irradiation state of irradiating the wall A inside the body cavity with the reference light an imaging part 9 for imaging the reflected light of the fluorescence and the reference light returned from the wall A inside the body cavity to the insertion part 2 and an image computation part 29 for calculating a difference between a correction imaging signal acquired by multiplying a correction factor determined according to the intensity of the reference light by a first imaging signal acquired in the first irradiation state and a second imaging signal acquired in the second irradiation state and generating fluorescence image signals.COPYRIGHT: (C)2012,JPO&INPIT【課題】導光部由来ノイズ光の影響を簡易な演算により除去し、病変組織と正常組織との区別が容易かつ鮮明な蛍光画像を取得する。【解決手段】体腔内に挿入される挿入部2と、挿入部2の基端側に配置され励起光と該励起光により発生される蛍光の波長帯域の少なくとも一部を含む参照光とを発生する光源部3と、励起光及び参照光を挿入部2の先端側に導光する導光部6と、励起光を体腔内壁Aに照射する第1の照射状態と参照光を体腔内壁Aに照射する第2の照射状態とを切替える照射制御部14と、体腔内壁Aから挿入部2に戻る蛍光及び参照光の反射光を撮像する撮像部9と、第1の照射状態において取得された第1の撮像信号に参照光の強度に応じて定められる補正係数を乗じて得られた補正撮像信号と第2の照射状態において取得された第2の撮像信号との差分を算出し蛍光画像信号を生成する画像演算部29と、を備える蛍光内視鏡装置1を提供する。【選択図】図1
