ZHOU, Jia,LI, Qingfeng,XU, John,LU, Patrick, Y.,SIMONENKO, Vero
申请号：
EP17865833
公开号：
EP3532071A4
申请日:
2017.10.30
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
The current invention provides a method of activating fibroblast and myofibroblast apoptosis in a tissue of a mammal, comprising administering to the tissue a therapeutically effective amount of a composition comprising an siRNA molecule that binds to an mRNA that codes for TGFBl protein in a mammalian cell, an siRNA molecule that binds to an mRNA that codes for COX-2 protein in a mammalian cell, and a pharmaceutically acceptable carrier comprising a pharmaceutically acceptable histidine-lysine polymer. The invention also provides additional methods for using this composition.
