FIELD: medicine.SUBSTANCE: invention refers to medicine, particularly to oncology, and may be applied in treating locally advanced breast cancer with tumour skin ulceration. That is ensured by CMF chemotherapy, 5-fluorouracil chemotherapy in the form of Koletex-5-fluor tissue applications and radiation therapy. The Koletex-5-fluor tissues are applied on the ulcer centre daily 2-3 times a day and changed every 2 days. The radiation therapy is performed in a mode of average dose fractionation on an area of a breast base and an area of regional lymph outflow. Herewith, 5-7 days before the radiation therapy, the ulcer area and the whole breast are coated with a thin layer of the Hydrogel Coletex-Phyto Tissue material 3 times a day. Additionally, the ulcer area is coated with the Coletex-Phyto textile tissues above the hydrogel material. The radiation directly covers the tissue and hydrogel. The ulcer borders are treated with the Hydrogel Coletex-Phyto Tissue material 2-3 times a day for the whole period of radiation. After the termination of the radiation therapy, the ulcer centre is coated with the Coletex-Phyto textile tissues, while the ulcer borders are treated with the Hydrogel Coletex-Phyto Tissue material for 1-2 weeks.EFFECT: implementing the method provides higher clinical effectiveness ensured by faster healing of tumour ulcers, reduced drug load, lower toxicity and enabled continuous radiation therapy.1 exИзобретение относится к медицине, а именно к онкологии, и может быть использовано для лечения местнораспространенного рака молочной железы с опухолевыми изъязвлениями кожи. Для этого проводят химиотерапию по схеме CMF, химиотерапию 5-фторурацилом в форме салфеток «Колетекс-5-фтур» и лучевую терапию. Салфетки «Колетекс-5-фтур» накладывают на центр язвы ежедневно 2-3 раза в день и меняют их каждые 2 дня. Лучевую терапию проводят в режиме среднего фракционирования дозы на область основания молочной железы и зоны регионарного лимфооттока. При этом за 5-7 дней до
