Russell-John KROM,James J. COLLINS,Prerna Saluja BHARGAVA,Michael Andrew LOBRITZ
申请号：
US15780668
公开号：
US20180355378A1
申请日:
2015.12.04
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Provided herein, in some embodiments, are engineered phagemids that comprise at least one synthetic genetic circuit, wherein the at least one synthetic genetic circuit comprises gene sequences encoding at least one non-lytic antimicrobial peptides (AMPs) and/or antibacterial toxin proteins, a stable origin of replication, and a bacteriophage-packaging signal, wherein the engineered phagemid does not comprise some or all gene sequences encoding bacteriophage proteins required for assembly of a bacteriophage particle.
