OOMURA, TOMOYUKI,PUDIPEDDI, MADHUSUDHAN,ROYCE, ALAN EDWARD,RUEGGER, COLLEEN,SASAKI, MASAKI,TAMURA, TOKUHIRO
申请号：
NZ59233904
公开号：
NZ592339A
申请日:
2004.04.06
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
A process for producing a pharmaceutical composition in the form of a solid formulation adapted for oral administration is disclosed, which comprises: (a) mixing an S1P receptor agonist with a sugar alcohol (b) milling and/or granulating the mixture obtained in (a) and (c) mixing the milled and/or granulated mixture obtained in (b) with a lubricant, wherein the S1P receptor agonist is selected from 2-amino-2-[2-(4-octylphenyl)ethyl]-propane-1,3-diol (FTY720), a pharmaceutically acceptable salt thereof or FTY720-phosphate.A pharmaceutical composition prepared by this process has a good level of content and blend uniformity (i.e. a substantially uniform distribution of the S1P receptor agonist throughout the composition), dissolution time and stability over long duration is obtained.
