This patent disclosure relates generally to a kind of yeast cell wall particulates load nanoparticles to deliver for receptor type distribution pattern nanoparticle. In particular, the present invention relates in trapping nanoparticle surface or in yeast glucan particles, for example, yeast glucal particle. The present invention is further directed to manufacture yeast cell wall particle and loads nanoparticle. The present invention also relates to use yeast cell wall particle particle to be used for the nanoparticle that receptor type distribution pattern conveys loading nanoparticle, such as the particle comprising drug.