A manufacturing method for a cyanoacrylate adhesive comprises the steps of (a) providing an adhesive base including a first cyanoacrylate monomer (b) providing a thickener including polycyanoacrylate, in which the polycyanoacrylate is made by the process comprising: providing a second cyanoacrylate monomer, adding ammonium hydroxide or alcoholic solution to perform polymerization, heating and drying the polymerized product at 30 to 100 DEG C and vaporizing to remove the ammonium hydroxide or alcoholic solution and (c) adding the thickener into the adhesive base. By using the thickener without containing an initiator or a promoter, the premature polymerization of the cyanoacrylate monomer can be prevented in the cyanoacrylate adhesive manufactured therewith, and the viscosity achieved can be widely applied to medical and surgical purposes.本發明係關於一種氰基丙烯酸酯黏合劑之製造方法,其步驟包括:(a)提供一黏合劑基體,該黏合劑基體包括第一氰基丙烯酸酯單體;(b)提供一增稠劑,該增稠劑包括聚氰基丙烯酸酯(polycyanoacrylate),其中,該聚氰基丙烯酸酯之製造方法包括:提供第二氰基丙烯酸酯單體;加入氫氧化銨(ammonium hydroxide)或醇類水溶液進行聚合反應;於30℃~100℃下加熱烘乾該聚合反應產物,並揮發去除該氫氧化銨或該醇類;以及(c)將該增稠劑加入該黏合劑基體中。藉由本發明不含起始劑或促進劑之增稠劑,其所製備的氰基丙烯酸酯黏合劑可避免氰基丙烯酸酯單體的過早聚合,並具所需黏度而可廣泛應用於醫療與手術上。
