A method of making a vascular phantom based on imaging data of vasculature of a subject. A mold having a core and a shell is constructed based on the imaging data. A liquid precursor is introduced into the mold and is cured. The mold is removed, leaving a model of the vasculature of the subject. A plaque component is fabricated by making a plaque mold and introducing liquid precursors containing T1 and T2 modifiers to mimic the T1 and T2 of portions of the plaque. The plaque components are attached to the vasculature using adhesive.
