Present disclose provides method and compositions, the patient of imbalance or damage for influencing motor function and control in treating. In one aspect, transgene product of the invention is transmitted to the spinal cord of subject by the way that the neurophilic viral vector of the recombination containing transgenosis is administered to brain. The viral vector delivery transgenosis by which susceptible and expresses the recombinant virus gene product of the coding to brain area. Composition is additionally provided to which transgene product is transmitted to the brain that the spinal cord of subject is administered to by the neurophilic viral vector by the recombination containing transgenosis subject.
