Method for producing disease model non-human animal, disease model non-human animal, drug screening method using the animal, and disease risk determination method
【Task】 The present invention relates to a method for causing or developing a particular disease or condition in an animal subjected to stress, particularly chronic stress, and elucidation of a process leading to the occurrence of the stress and the disease or condition for the disease or condition. The purpose is to provide useful tools for research and development such as prevention or treatment. [Solution] The present invention provides a method for producing a disease model non-human animal having inflammation in brain blood vessels, the model non-human animal, a method for screening a drug using the model non-human animal, and the presence or absence of brain blood vessel inflammation as an index. The present invention relates to a method for determining a disease risk, and a medicament for preventing and / or treating progressive multiple sclerosis and the like. According to the present invention, it becomes possible to develop a medicine for the above-mentioned diseases and the like and to carry out research for elucidating the onset mechanism. Moreover, it becomes possible to determine the risk of developing or developing progressive multiple sclerosis and the like, and to prevent and / or treat progressive multiple sclerosis and the like. [Selection diagram] Fig. 1【課題】 本発明は、ストレス、特に慢性的なストレスを受けた動物に特定の疾患又は症状を罹患又は発症させる方法、そのストレスと疾患又は症状の罹患又は症状に至る過程の解明を通じて、当該疾患又は症状に対する予防又は治療等の研究開発に有用なツールを提供することを目的とする。【解決手段】 本発明は、脳内血管に炎症を有する疾患モデル非ヒト動物の製造方法、当該モデル非ヒト動物、当該モデル非ヒト動物を用いた薬剤のスクリーニング方法、脳内血管の炎症の有無を指標とする疾患リスクの判定方法、並びに進行性多発性硬化症等を予防及び／又は治療するための医薬に関する。本発明によると、前記疾患等に対する医薬の開発や、発症機序解明のための研究が可能になる。また、進行性多発性硬化症等の罹患又は発症リスクの判定、並びに進行性多発性硬化症等の予防及び／又は治療が可能になる。【選択図】図１
