Exoprother Medical Ltd.;Alexander TENDLER;Lana VOLOKH
发明人:
Alexander TENDLER,Lana VOLOKH
申请号：
IL26948319
公开号：
IL269483D0
申请日:
2019.09.19
申请国别(地区):
IL
年份:
2019
代理人:
摘要：
A method of obtaining cell derived vesicles comprising an active wild-type p53 is disclosed. The method comprising: (i) isolating cell derived vesicles from a biological sample comprising cells； and (ii) treating the cell derived vesicles with a DNA damaging agent, or the method comprising: (i) treating cells with a DNA damaging agent； and (ii) isolating cell derived vesicles from a biological sample comprising the cells. A proteinaceous preparation comprising cell derived vesicles and a pharmaceutical composition comprising the proteinaceous preparation are also disclosed. Methods of treating a disease, disorder or condition associated with a mutant or a nonfunctional p53 protein and methods of inducing apoptosis of a target cell comprising a mutant or a nonfunctional p53 protein are also disclosed.
