Crystalline form of an inhibitor of MDM2/4 and p53 interaction

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专利权人:

Novartis AG

发明人:

Berghausen, Joerg,Ren, Haixia

申请号：

AU2011331095

公开号：

AU2011331095A1

申请日:

2011.11.17

申请国别(地区):

AU

年份:

2013

代理人:

摘要：

A crystalline form of (S)-1-(4-Chloro-phenyl)-7-isopropoxy-6-methoxy-2-(4-{methyl-[4-(4- methyl-3-oxo-piperazin-1-yl)-trans-cyclohexylmethyl]-amino}-phenyl)-1,4dihydro-2H- isoquinolin-3-one, which is useful in the treatment of a disease or disorder associated with the interaction between p53, or variants thereof, and MDM2 and/or MDM4, or variants thereof, respectively, (I).

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