Crystalline form of an inhibitor of MDM2/4 and p53 interaction

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专利权人:

Joerg Berghausen

发明人:

Joerg Berghausen,Haixia Ren

申请号：

US13988227

公开号：

US09073898B2

申请日:

2011.11.17

申请国别(地区):

US

年份:

2015

代理人:

摘要：

A crystalline form of (S)-1-(4-Chloro-phenyl)-7-isopropoxy-6-methoxy-2-(4-{methyl-[4-(4-methyl-3-oxo-piperazin-1-yl)-trans-cyclohexylmethyl]-amino}-phenyl)-1,4-dihydro-2H-isoquinolin-3-one, which is useful in the treatment of a disease or disorder associated with the interaction between p53, or variants thereof, and MDM2 and/or MDM4, or variants thereof, respectively.

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中国工程科技知识中心

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