Vaccine comprising a peptide bound to a pharmaceutically acceptable carrier, said peptide having the amino acid sequence(Formula I)(SEQ ID NO: 1)(X1)m(X2)n(X3)oX4X5HPX6,for treating and/or preventing a physical disorder associated with the renin-activated angiotensin system, wherein X1 is G or D,X2 is A, P, M, G, or R,X3 is G, A, H, or V, X4 is S, A, D, or Y,X5 is A, D, H, S, N, or I,X6 is A, L or F,wherein m, n and o are independently 0 or 1 under the premise that when o is 0 m and n are 0 and when n is 0 m is 0, and wherein the peptide is not DRVYIHPF (SEQ ID NO:4).
