1-(Arylmethyl)quinazoline-2,4(1H,3H)-diones as PARP inhibitors and the use thereof

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专利权人:

Xiuhua Hu;Ye Edward Tian;Sui Xiong Cai

发明人:

Sui Xiong Cai,Ye Edward Tian,Xiuhua Hu

申请号：

US14006722

公开号：

US09290460B2

申请日:

2012.03.31

申请国别(地区):

US

年份:

2016

代理人:

摘要：

Disclosed are 1-(arylmethyl)quinazoline-2,4(1H,3H)-diones thereof, represented by the Formula (I) wherein Ar, R1-R6 are defined herein. Compounds having Formula (I) are PARP inhibitors. Therefore, compounds of the invention may be used to treat clinical conditions that are responsive to the inhibition of PARP activity.

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