IMMUNISATION DE PEPTIDE À BOUCLE C EXTRACELLULAIRE D'AQUAPORINE-4 EXTRÊMEMENT SOLUBLE POUR LE TRAITEMENT DE NEUROMYÉLITE OPTIQUE AIGUË

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专利权人:

The Johns Hopkins University

发明人:

申请号：

EP15796927.0

公开号：

EP3145528A4

申请日:

2015.05.19

申请国别(地区):

EP

年份:

2018

代理人:

摘要：

The present invention provides pharmaceutical compositions for treating neuromyelitis optica (NMO) comprising a therapeutically effective amount of loop C sequence-containing peptide of aquaporin-4 (AQP4) water channel, or a therapeutically effective fragment or variant thereof. The invention also provides methods for treating NMO by administering therapeutically effective amounts of loop C sequence-containing peptide(s) of AQP4, optionally in an immunosuppressive setting, and also provides diagnostics for detection of NMO in a subject, screening methods for identification of NMO-treating therapeutics and NMO model systems.

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中国工程科技知识中心

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http://www.ckcest.cn/home/