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FIBRILLATION-RESISTANT INSULIN AND INSULIN ANALOGUES
专利权人:
Michael Weiss
发明人:
Michael Weiss
申请号:
US13472833
公开号:
US20120316107A1
申请日:
2012.05.16
申请国别(地区):
US
年份:
2012
代理人:
摘要:
A fibrillation-resistant insulin analogue may be a single-chain insulin analogue or a physiologically acceptable salt thereof, containing an insulin A chain sequence or an analogue thereof and an insulin B chain sequence or an analogue thereof connected by a polypeptide of 4-10 amino acids. The fibrillation-resistant insulin analogue preferably displays less than 1 percent fibrillation with incubation at 37° C. for at least 21 days. A single-chain insulin analogue displays greater in vitro insulin receptor binding than normal insulin while displaying less than or equal binding to IGFR than normal insulin. The fibrillation-resistant insulin may be used to treat a patient using an implantable or external insulin pump, due to its greater fibrillation resistance.
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