THEODOR STOLL,JEAN PLANCHER,SABINE MARC - KOLCZEWSK,DELPHINE GAUFRETEAU
申请号：
ARP160103364
公开号：
AR106589A1
申请日:
2016.11.04
申请国别(地区):
AR
年份:
2018
代理人:
摘要：
The compounds can be used for the treatment of CNS diseases relating to positive (Psychosis) and negative symptoms of schizophrenia, Substance Abuse,Addiction to drugs and Alcohol, obsessive compulsive disorders, Cognitive imbalance, bipolar disorders, mood disorders, severe depressionTreatment resistant Depression, Anxiety Disorders, Alzheimer's disease, autism, Parkinson's disease, Chronic Pain, borderline Personality Disorder,The neurodegenerative disease, Sleep Disorders, Chronic Fatigue Syndrome, stiffness, inflammatory disease, Huntington's disease, Asthma, ADHDAmyotrophic lateral sclerosis, the effects of Arthritis, autoimmune disease, viral and fungal infections, cardiovascular diseases,Eye diseases and Retinal inflammation, balance problems, Epilepsy and Neurodevelopmental Disorders concomitant With Epilepsy.Claim 1: a compound of the formula (1) in which a is phenyl or heteroaryl Group of six links, which contains one or two n ATOMS,Among the remains of the chosen Group of formulas (2)； or the Amine Group nr u00b9r u00b2 - together with the two neighboring carbon Atoms can form a group to further FUSED ring,Among the remains of the chosen Group of Formulae (3)； r u00b9 / R u00b2 with Independence between C (OR) are Hydrogen, Lower alkyl, cycloalkyl, - (ch u2082 u2082 Lower alkoxy) -,Or oxetanilo or lower alkyl； and r u00b9 R u00b2 together with the N Atom, which are United,Can form the Group selected from the group of formulas (4)； r u00b3 is Hydrogen or lower alkyl； and a pharmaceutically acceptable Salt of sameA racemic mixture and / or its enantiomers or optical isomers and / or stereoisomers of the same.Los compuestos pueden emplearse para el tratamiento de enfermedades del SNC relativas a los síntomas positivos (sicosis) y negativos de la esquizofrenia, el abuso de sustancias, la adicción al alcohol y a las drogas, los trastornos obsesivo-compulsivos, el desequilibrio cognitivo, los trastornos bipolares, los trastornos del humor, la depresión seve
