THEODOR STOLL,JEAN PLANCHER,THORSTEN MARC - MUSER,SABINE KOLCZEWSKI,ROLAND HUMM,HANS HILPER,DELPHINE GAUFRETEAU
申请号：
ARP160103365
公开号：
AR106590A1
申请日:
2016.11.04
申请国别(地区):
AR
年份:
2018
代理人:
摘要：
This application relates to indolin-2-one Derivatives of General formula (1) where a is a phenyl or heteroaryl Group of six members, which contains one or two n ATOMS,Among the remains of the selected Group of formulas (2)； or the Oxygen Atom can form together with two adjacent carbon atoms from a Condensed Ring Group additionalAmong the remains of the selected Group of Formulae (3)； r u00b9 is Hydrogen, Lower alkyl, substituted with lower alkyl or Halogen oxetanilo； R u00b2 is Hydrogen, Lower alkyl, alkoxy, LowerCycloalkyl or Halogen； -- the dotted line may be nothing - or - ch u2082； and a pharmaceutically acceptable Salt thereof, with a racemic mixture.Or with their corresponding enantiomer and / or optical Isomer and / or stereoisomer thereof.The compounds can be used in the treatment of CNS diseases related (Psychosis) and negative positive symptoms of schizophrenia, Substance Abuse,Alcohol and Drug Addiction, obsessive compulsive disorders, cognitive disorders, bipolar disorders, mood disorders, major depression, Treatment resistant depressionAnxiety Disorders, Alzheimer's disease, autism, Parkinson's disease, Chronic Pain, the borderline Personality Disorder, Sleep Disorders, Neurodegenerative Diseases,Chronic Fatigue Syndrome, stiffness, inflammatory diseases, Asthma, ADHD, Huntington's disease, Amyotrophic lateral sclerosis, the effects on arthritis, autoimmune diseases,Viral and fungal infections, cardiovascular diseases, inflammatory diseases of the retina and Vision and balance problemsEpilepsy and Neurodevelopmental Disorders with comorbid Epilepsy.La presente solicitud se refiere a derivados de indolin-2-ona de fórmula general (1) en donde A es fenilo o un grupo heteroarilo de seis miembros, que contiene uno o dos átomos de N, seleccionados entre los restos del grupo de fórmulas (2)； o el átomo de oxígeno puede formar junto con dos átomos de carbono colindantes a partir del grupo A un anillo condensado adicional, seleccionado entre los restos del gru
