PROCÉDÉ DE DIAGNOSTIC D'UNE MALADIE AUTO-IMMUNE, BIOMARQUEUR DE DIAGNOSTIC D'UNE MALADIE AUTO-IMMUNE, ET AGENT DE PRÉVENTION OU DE TRAITEMENT D'UNE MALADIE AUTO-IMMUNE
National Center of Neurology and Psychiatry;The University Of Tokyo;School Corporation, Azabu Veterinary Medicine Educational Institution;Juntendo Educational Foundation
发明人:
申请号：
EP16839378.3
公开号：
EP3342864A1
申请日:
2016.08.26
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
Provided is a diagnosis method for an autoimmune disease, including a step of measuring the relative abundances of bacteria included in a fecal sample collected from a test subject； and a step of performing the following (1) or (2): (1) in a case in which relative abundance of a bacterium whose nucleotide sequence of 16S ribosomal RNA gene has an identity of 99% or higher with nucleotide sequence set forth in SEQ ID NO:3 or SEQ ID NO:4, is large compared to the relative abundance in healthy subject, determining that the test subject has contracted, or has a high risk of contracting, the autoimmune disease； and (2) in a case in which relative abundance of a bacterium whose nucleotide sequence of 16S ribosomal RNA gene has an identity of 99% or higher with any one of nucleotide sequences set forth in SEQ ID NO:5 to SEQ ID NO:23, is small compared to the relative abundance in healthy subject, determining that the test subject has contracted, or has a high risk of contracting, the autoimmune disease.
