Several methods are used to better define and optimize item sets for short-term memory tests with respect to chunkiness and homogeneity, including dynamically changing the test item set to make it have as few chunkable items as possible. A resulting item set allows the test taker to see in an intuitive way how her or his memory has a limited capacity of, typically, three non-chunkable items. The test can be done, inter alia, via computer, via the telephone, and via robocalling. It can, inter alia, provide mass screening for Alzheimers disease and detect early Alzheimers disease in drug trials.