BRADNER, JAMES,BUCKLEY, DENNIS,ISHOEY, METTE,WINTER, GEORG
申请号：
CA3042301
公开号：
CA3042301A1
申请日:
2017.11.22
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present application provides bifunctional compounds of Formula (X): Targeting Ligand or an enantiomer, diastereomer, or stereoisomer thereof, or pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, which act as protein degradation inducing moieties for protein kinases. The present application also relates to methods for the targeted degradation of one or more protein kinases through the use of the bifunctional compounds that link a ubiquitin ligase-binding moiety to a ligand that is capable of binding to one or more protein kinases which can be utilized in the treatment of disorders modulated by protein kinases.
