DEGRADATION DE LA PROTEINE CONTENANT UN BROMODOMAINE 9 (BRD9) PAR CONJUGAISON D'INHIBITEURS DE BRD9 AVEC UN LIGAND DE LA LIGASE E3 ET PROCEDES D'UTILISATION
BUCKLEY, DENNIS,BRADNER, JAMES,REMILLARD, DAVID IAN
申请号:
CA3025806
公开号:
CA3025806A1
申请日:
2017.06.23
申请国别(地区):
CA
年份:
2017
代理人:
摘要:
The present application provides bifunctional compounds of Formula (I): or an enantiomer, diastereomer, or stereoisomer thereof, or pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, which act as protein degradation inducing moieties for bromodomain-containing protein 9 (BRD9). The present application also provides methods for the targeted degradation of BRD9 through the use of the bifunctional compounds that link a ubiquitin ligase-binding moiety to a ligand that is capable of binding to BRD9 which can be utilized in the treatment of disorders modulated by BRD9.