GRAY, NATHANAEL S.,WANG, JINHUA,DOBROVOLSKY, DENNIS
申请号：
CA3085457
公开号：
CA3085457A1
申请日:
2019.01.29
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The present application provides bifunctional compounds of Formula X or an enantiomer, diastereomer, or stereoisomer thereof, or pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, which act as protein degradation inducing moieties for Bruton's tyrosine kinase (BTK). The present application also relates to methods for the targeted degradation of BTK through the use of bifunctional compounds that link a ubiquitin ligase-binding moiety to a ligand that is capable of binding to BTK which can be utilized in the treatment of disorders modulated by BTK.
