James BRADNER,Dennis BUCKLEY,Mette Ishoey ROSENBAUM,Georg WINTER
申请号：
US16343977
公开号：
US20190263823A1
申请日:
2017.11.22
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present application provides bifunctional compounds of Formula (X):or an enantiomer, diastereomer, or stereoisomer thereof, or pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, which act as protein degradation inducing moieties for protein kinases. The present application also relates to methods for the targeted degradation of one or more protein kinases through the use of the bifunctional compounds that link a ubiquitin ligase-binding moiety to a ligand that is capable of binding to one or more protein kinases which can be utilized in the treatment of disorders modulated by protein kinases.
