This invention relates to a topical, cosmetic or dermatological composition, comprising a 1,3 diglyceride having the general formula (I): in which the radicals R1 and R2 represent, independently of one another, a C13 to C40 saturated and linear alkyl radical, and at least one cosmetic or dermatological excipient for a topical application on the skin.such a composition, or a 1,3 diglyceride having the formula (I), for its use in protecting the skin, in countering the weakening of the skin barrier and in preventing or reducing the penetration of exogenous molecules into the skin following a weakening of the skin barrier.本發明係有關於一種局部用、化妝或皮膚組成物，其包含具有通式(I)之1,3雙酸甘油酯：其中基(radicals)R1及R2彼此獨立地表示C13至C40飽和及線性的烷基基(radical)，以及供局部施用於皮膚之至少一化妝或皮膚賦形劑。本發明亦有關於此一種組成物，或具有式(I)之1,3雙酸甘油酯，其供用於保護皮膚、抵抗皮膚屏障之弱化，以及在皮膚屏障之弱化後，防止或降低外生性分子之穿透的用途。
