Esters d'acide aminé d'amide des médicaments anti-inflammatoires non-stéroïdes (nsaid) en tant qu'inhibiteurs puissants de la croissance de cellules tumorales du colon
The present invention refers to amides of NSAIDs, preferably of naproxen, amino acids esters having the chemical structure of formula Iwherein R2 is an amino acid ester residue, or any racemic form, prodrug, enantiomer, or analog of the substance, or pharmaceutical composition comprising such compound, for use as a medicament for the treatment or prevention of cancer or a proliferative disease or disorder. Preferably, the compounds may be used for the treatment or prevention of colorectal cancers. The invention also comprises methods for the treatment or prevention of a proliferative disease or disorder, comprising administering to a mammal in need thereof an effective amount of a therapeutic agent, wherein the therapeutic agent comprises such amide of naproxen amino acids esters.
