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Esters d'acide aminé d'amide des médicaments anti-inflammatoires non-stéroïdes (nsaid) en tant qu'inhibiteurs puissants de la croissance de cellules tumorales du colon
专利权人:
King Saud University
发明人:
申请号:
EP12153878.9
公开号:
EP2623098A1
申请日:
2012.02.03
申请国别(地区):
EP
年份:
2013
代理人:
摘要:
The present invention refers to amides of NSAIDs, preferably of naproxen, amino acids esters having the chemical structure of formula Iwherein R2 is an amino acid ester residue, or any racemic form, prodrug, enantiomer, or analog of the substance, or pharmaceutical composition comprising such compound, for use as a medicament for the treatment or prevention of cancer or a proliferative disease or disorder. Preferably, the compounds may be used for the treatment or prevention of colorectal cancers. The invention also comprises methods for the treatment or prevention of a proliferative disease or disorder, comprising administering to a mammal in need thereof an effective amount of a therapeutic agent, wherein the therapeutic agent comprises such amide of naproxen amino acids esters.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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