БЕШЕ Анн Шанталь (NL),ВАН ДЕЙКХЕЙЗЕН-РАДЕРСМА Римке (NL),СТИГТЕР Мартин (NL),БЕЗЕМЕР Ерун Маттейс (NL)
申请号：
RU2010138739/15
公开号：
RU2010138739A
申请日:
2010.09.20
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
1. A method of obtaining a pharmaceutical composition for controlled release containing microparticles, which include a polymer carrier and one or more alpha interferons, where the polymer carrier includes one or more block copolymers consisting of poly (ethylene glycol) terephthalate (PEGT) and poly (butylene terephthalate ) (PBT), where most microparticles essentially do not have pores with a diameter greater than about 5 microns, including the steps of:! (a) the manufacture of an emulsion containing! (aa) the internal aqueous phase containing the active compound, and! (ab) an external organic phase comprising a biodegradable polymer and at least one organic solvent； ! (b) solidification of the biodegradable polymer into microparticles when removing from the emulsion prepared in step (a) at least a portion of the organic solvent； ! (c) collecting and drying the microparticles obtained in step (b),! where step (b) is carried out by emulsifying an emulsion prepared in step (a) in a conjugated aqueous phase to obtain an i / m / v double emulsion, where the conjugated aqueous phase contains an osmotic agent. ! 2. The method according to claim 1, in which most of the microparticles essentially do not have pores with a diameter of more than about 2 microns. ! 3. The method according to claim 1, in which the interferon is an alpha interferon. ! 4. The method according to claim 1, in which interferon is a recombinant product obtained from genetically engineered cells or organisms, and these cells or organisms are preferably selected from cells or organisms of mammals, insects, bacteria, yeast, fungi and higher plants or organisms. ! 5. The method according to claim 1, in the cat1. Способ получения фармацевтической композиции для контролируемого высвобождения, содержащей микрочастицы, которые включают полимерный носитель и один или более альфа-интерферонов, где полимерный носитель включает один или более блок-сополимеров, состоящих из поли(этиленгликоль)терефталата (ПЭГТ)
