The present invention relates to an inhalation formulation of a drug in the form of a dry powder for inhalation administration that can be delivered as-is by an inhaler and provides high delivery capacity, respiratory capacity, and stability. In particular, the present invention provides, at least in powder (a1), an active substance in an amount greater than 1% by weight of this powder or a pharmaceutically acceptable salt thereof, leucine in an amount of 5 to 70% by weight of said powder, A mixture of a first powder comprising powder (a1) comprising sugar in an amount of 20-90% by weight of the powder and a first lactose having an X50 of 35-75 μm and a second lactose having an X50 of 1.5-10 μm And a pharmaceutical composition for inhalation use in the form of a powder comprising a second powder in which the content of the first lactose and the second lactose in the mixture is 85% to 96% and 4% to 15%, respectively Relates to a functional composition. The weight ratio of the first powder to the second powder is 1/5 to 1/100 and the composition has a fine particle fraction (FPF) greater than 60% and a delivery fraction (DF) greater than 85%. .本発明は、吸入器でそのまま送達可能で、高い送達能、呼吸能、および安定性を提供する吸入投与用の、乾燥粉末の形態の薬剤の吸入配合物に関する。特に、本発明は、少なくとも、粉末（ａ１）において、この粉末の１重量％超の量の活性物質または薬学的に許容可能なその塩、前記粉末の５～７０重量％の量のロイシン、その粉末の２０～９０重量％の量の糖を含む粉末（ａ１）を含む第１粉末と、３５～７５μｍのＸ５０を有する第１ラクトースの１．５～１０μｍのＸ５０を有する第２ラクトースとの混合物を含み、この混合物中の第１ラクトースと第２ラクトースの含量が、それぞれ、８５％～９６％および４％～１５％である第２粉末とを含む粉末の形態での吸入使用のための薬学的組成物に関する。第１粉末と第２粉末の重量比は、１／５～１／１００であり、本組成物は、６０％超の微粒子画分（ＦＰＦ）および８５％超の送達画分（ＤＦ）を有する。
