HCV NS-3 SERINE PROTEASE INHIBITORS

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专利权人:

MEDIVIR AB

发明人:

ROSENQUIST, ASA,THORSTENSSON, FREDRIK,JOHANSSON, PER-OLA,KVARNSTROM, INGEMAR,AYESA, SUSANA,KLASSON, BJORN,RAKOS, LASZLO,SAMUELSSON, BERTIL

申请号：

CA2552317

公开号：

CA2552317C

申请日:

2005.01.28

申请国别(地区):

CA

年份:

2013

代理人:

摘要：

Compounds of the formula (F) where the variables are as defined in thespecification inhibit the NS3 protease of flavivirus sych as hepatitis C virus(HCV). The compounds comprise a novel linkage between a heterocyclic P2 unitand those portions of the inhibitor more distal to the nominal cleavage siteof the native substrate, which linkage reverses the orientation of peptidicbonds on the distal side relative to those proximal to the cleavage site.

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